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A Diels-Alder reaction conducted within the parameters of aqueous organocatalysis: still just smoke and mirrors

G Neil Stowe and Kim D Janda

Tetrahedron Lett 52(17):3 (2011) PMID 21516231 PMCID PMC3079225

Conducting reactions using water as solvent is a highly prized goal for the organic chemist. Based upon recent literature and our continuing interest in the field of aqueous organocatalysis, we tested the scope of an enamine based Diels-Alder reaction using (+/-)-nornicotine, proline, and a proline derivative as aqueous organocatalysts. Unfortunately, none of the examined catalysts under aqueous conditions proved useful, leaving the aqueous Diels-Alder reaction as an elusive goal.

Copyright © 2011 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.tetlet.2010.10.134
Version: za2963e q8za5 q8zba q8zc9 q8zdd q8zeb q8zf5 q8zg9
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