Advanced search×

Isoniazid-induced pellagra.

Serap Gunes SG Bilgili, Ayse Serap AS Karadag, Omer O Calka, and Faruk F Altun

Cutan Ocul Toxicol 30(4):317-9 (2011) PMID 21517721

Pellagra is characterized by dermatitis, diarrhea, dementia and eventually death occurring as a result of niacin or its precursor tryptophan deficiency. Although pellagra is a well-known complication of isoniazid (INH) therapy, the clinical diagnosis may be missed or delayed that may cause life-threatening consequences. Due to the diversity of pellagra-related signs and symptoms, the diagnosis can be made with an appropriate index of suspicion. We report a 7-year-old boy presenting with INH-induced pellagra that resolved after the administration of the niacin therapy.

DOI: 10.3109/15569527.2011.574303
Version: za2963e q8za6 q8zb4 q8zc0 q8zd6 q8zed q8zf6 q8zge

Similar articles you may find interesting…

  1. Cross-reactions among hair dye allergens.
    David A DA Basketter and John J English

    Cutan Ocul Toxicol 28(3):104-6 (2009) PMID 19552541

    Hair dye chemicals other than PPD may be of importance, but the presently tested materials, with the possible exception of PTD, are normally positive only when a PPD-positive reaction is also present, suggesting that their use in patch testing in hair dye allergy is likely to be of limited value....
  2. In vitro and in vivo evaluation of carboplatin delivery to the eye using hydrogel-iontophoresis.
    Esther E Eljarrat-Binstock, Abraham J AJ Domb, ... Jacob J Pe'er

    Curr Eye Res 33(3):269-75 (2008) PMID 18350438

    Similar drug concentrations were obtained in all experimental groups, in in vitro and in vivo studies, regardless of the iontophoretic current applied. A 20-mm penetration depth was found for carboplatin at the agar model. High drug levels were found at the sclera and retina, while lower levels were...