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Granulocyte-colony stimulating factor protects memory impairment in the senescence-accelerated mouse (SAM)-P10.

Cuiping C Zhao, Zhaohong Z Xie, Ping P Wang, Yun Y Wang, Chao C Lai, Zhengyu Z Zhu, Zhen Z Liu, Yanbin Y Cong, Yanxin Y Zhao, Chengyun C Zheng, and Jianzhong J Bi

Neurol Res 33(4):354-9 (2011) PMID 21535933

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with memory impairment in elderly people. At present, AD remains incurable. More and more evidences have suggested that granulocyte-colony stimulating factor (G-CSF) has important non-hematopoietic neuroprotective functions in central nervous system. The present study was designed to investigate the therapeutic potential of G-CSF in the senescence-accelerated mouse prone strain (SAM-P10) mice, a mouse model of senile dementia.

DOI: 10.1179/016164110X12807570509970
Version: za2963e q8za1 q8zba q8zc5 q8zd4 q8ze0 q8zf3 q8zg7

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