Advanced search×

Small bowel adenocarcinoma copy number profiles are more closely related to colorectal than to gastric cancers.

J C JC Haan, T E TE Buffart, P P PP Eijk, M A MA van de Wiel, W N WN van Wieringen, P D PD Howdle, C J J CJ Mulder, C J CJ van de Velde, P P Quirke, I D ID Nagtegaal, N C T NC van Grieken, H H Grabsch, G A GA Meijer, and B B Ylstra

Ann Oncol 23(2):367-74 (2012) PMID 21586687

Small bowel adenocarcinoma (SBA) is a rare cancer and consequently, the options for clinical trials are limited. As they are treated according to either a colorectal or a gastric cancer regimen and the molecular biology of a tumor is a pivotal determinant for therapy response, chromosomal copy number aberrations were compared with the colorectal and gastric adenocarcinomas. Materials and methods: A total of 85 microsatellite stable (MSS) adenocarcinomas from the stomach, colorectum and small bowel were selected from existing array comparative genomic hybridization (aCGH) datasets. We compared the aCGH profiles of the three tumor sites by supervised analysis and hierarchical clustering.

DOI: 10.1093/annonc/mdr122
Version: za2963e q8zac q8zb1 q8zc7 q8zdb q8zea q8zf2 q8zg6

Similar articles you may find interesting…

  1. Selective Blockade of DCAMKL-1 Results in Tumor Growth Arrest by a Let-7a MicroRNA-Dependent Mechanism
    Sripathi M Sureban, Randal May, ... Courtney W Houchen

    Gastroenterology 137(2):649-659.e2 (2009) PMID 19445940

    DCAMKL-1 is a negative regulator of let-7a miRNA biogenesis in intestinal stem and colorectal cancer cells; it could represent a novel target for anti-cancer stem cell-based strategies....
    View PDF
  2. [Adenocarcinoma and intestinal duplication of the ileum. Report of one case].
    Marcelo A MA Beltrán, Carlos C Barría, ... Karina S KS Cruces

    Rev Med Chil 137(10):1341-5 (2009) PMID 20011941

    We report a 36 year-old female admitted to the emergency room due to abdominal pain. Computed abdominal tomography demonstrated small bowel loops surrounding a tubular cystic structure and peritoneal free fluid. The surgical exploration revealed multiple malignant implants covering the visceral and...
    PDF not found
  3. Gastrointestinal dissemination of mucosa-associated lymphoid tissue lymphoma: computed tomographic findings.
    Hye Jin Kim, Hyun Kwon Ha, ... Ah Young Kim

    J Comput Assist Tomogr 34(2):187-92 (2010) PMID 20351501

    Despite its rarity, MALT lymphoma can disseminate into the GI tract in the form of circumferential bowel wall thickening or localized polypoid mass with or without gastric involvement....