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HPV16 E2 could act as down-regulator in cellular genes implicated in apoptosis, proliferation and cell differentiation.

Eric Ramirez-Salazar, Federico Centeno, Karen Nieto, Armando Valencia-Hernandez, Mauricio Salcedo, and Efrain Garrido

Virol J (2011) PMID 21599968

Human Papillomavirus (HPV) E2 plays several important roles in the viral cycle, including the transcriptional regulation of the oncogenes E6 and E7, the regulation of the viral genome replication by its association with E1 helicase and participates in the viral genome segregation during mitosis by its association with the cellular protein Brd4. It has been shown that E2 protein can regulate negative or positively the activity of several cellular promoters, although the precise mechanism of this regulation is uncertain. In this work we constructed a recombinant adenoviral vector to overexpress HPV16 E2 and evaluated the global pattern of biological processes regulated by E2 using microarrays expression analysis.

DOI: 10.1186/1743-422X-8-247
Version: za2963e q8za1 q8zb9 q8zcf q8zdf q8ze2 q8zf7 q8zgc
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