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Chromene induces apoptosis via caspase-3 activation in human leukemia HL-60 cells

Food and Chemical Toxicology 49(9):1998 (2011) PMID 21600262

Highlights ► We study the potential anti-tumor effects of chromene on HL-60 cells. ► SE showed significant inhibitory effects on the proliferation of HL-60 cells. ► There is no cytotoxicity of SE on normal cell lines in the tested concentrations. ► The apoptosis of HL-60 cells induced by SE was associated with the downregulation of Bcl-xL, and caspase-3 activation.

DOI: 10.1016/j.fct.2011.05.011