Advanced search×

Preparation and anti-bacterial properties of a temperature-sensitive gel containing silver nanoparticles.

Meiwan M Chen, Xin X Pan, Hongmei H Wu, Ke K Han, Xiaobao X Xie, D E DE Wedge, M A MA Repka, and Chuanbin C Wu

Pharmazie 66(4):272-7 (2011) PMID 21612154

The purpose of this study was to prepare a temperature-sensitive gel containing silver nanoparticles and to investigate its anti-bacterial properties in vitro. The aqueous gel was prepared using Pluronic F127 (18-22%) and Pluronic F68 (3-9%) in a cold method to obtain a proper gelation temperature at 37 degrees C. Viscoelastic properties of the system were measured by rheological measurements and the physicochemical properties were evaluated by MJ-22 Dial-reflex metaloscope and Zetasizer Nano ZS90. The in vitro antimicrobial activity was evaluated by a disk diffusion test, minimum inhibitory concentration, and minimum bactericidal concentration. A temperature-sensitive gel containing silver nanoparticles with 20 wt% F127 and 6 wt% F68 had suitable fluidity at 25 degrees C and was semi-solid at 37 degrees C. Silver nanoparticle size averaged 78.0 nm. The gel optimized formulation achieved a suitable viscosity. The MIC and MBC of the gel ranged from 1.0 to 2.0 mg/L against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The activity of the gel against these three species was significantly enhanced (p

Version: za2963e q8za7 q8zb7 q8zc1 q8zdd q8ze3 q8zf5 q8zge

Similar articles you may find interesting…

  1. Collection and preservation of frozen microorganisms.
    Rosamaria R Tedeschi and Paolo P De Paoli

    Methods Mol Biol (2011) PMID 20949399

    The storage of the different microorganisms over long periods is necessary to ensure reproducible results and continuity in research and in biomedical processes and also for commercial purposes. Effective storage means that a microorganism is maintained in a viable state free of contamination or gen...
  2. Hydrogen peroxide vapor: a novel method for the environmental control of lactococcal bacteriophages.
    Jonathan A Otter and Andrea Budde-Niekiel

    J Food Prot 72(2):412-4 (2009) PMID 19350989

    We examined the in vitro efficacy of hydrogen peroxide vapor (HPV) for the inactivation of two lactococcal bacteriophages dried onto stainless steel discs. A more than 6-log reduction was achieved on both bacteriophages compared with unexposed controls by 50 min of HPV exposure in an isolator. HPV m...
  3. Ethosomes for the delivery of anti-HSV-1 molecules: preparation, characterization and in vitro activity.
    R R Cortesi, L L Ravani, ... E E Esposito

    Pharmazie 65(10):743-9 (2010) PMID 21105576

    This paper describes the production, characterization and in vitro activity of ethosomes containing two molecules with antiviral activity, such as acyclovir (ACY) and N1-beta-D-ribofuranosyl-pyrazole [3,4d]pyridazin-7(6p-chlorine-phenyl)-one nucleoside (N1CP). Ethosomes were prepared and morphologica...