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The role of lipid droplets in metabolic disease in rodents and humans.

Andrew S AS Greenberg, Rosalind A RA Coleman, Fredric B FB Kraemer, James L JL McManaman, Martin S MS Obin, Vishwajeet V Puri, Qing-Wu QW Yan, Hideaki H Miyoshi, and Douglas G DG Mashek

J Clin Invest 121(6):2102-10 (2011) PMID 21633178

Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.

DOI: 10.1172/JCI46069
Version: za2963e q8za0 q8zbc q8zc4 q8zdf q8zed q8zf8 q8zgf
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