Advanced search×

The Membrane-Activated Chelator Stroke Intervention (MACSI) Trial of DP-b99 in acute ischemic stroke: a randomized, double-blind, placebo-controlled, multinational pivotal phase III study.

Gilad G Rosenberg, Natan N Bornstein, Hans-Christoph HC Diener, Philip B PB Gorelick, Ashfaq A Shuaib, Kennedy K Lees, and

Int J Stroke 6(4):362-7 (2011) PMID 21645269

Zinc is both a direct neurotoxin and a signaling mediator in multiple early and late detrimental processes following ischemia. DP-b99, a lipophilic moderate-affinity chelator of zinc, is a first-in-class multitargeted neuroprotective agent for ischemic stroke. DP-b99 has completed several Phase I studies and two double-blind placebo-controlled Phase II trials, which supported the safety of DP-b99 and were consistent with a beneficial effect on poststroke recuperation.

DOI: 10.1111/j.1747-4949.2011.00608.x
Version: za2963e q8za8 q8zbe q8zce q8zdb q8ze1 q8zf4 q8zgd

Similar articles you may find interesting…

  1. [Pulmonary hypertension in end-stage renal disease: three case reports].
    S S Pabst, C C Hammerstingl, ... D D Skowasch

    Dtsch Med Wochenschr 136(18):944-7 (2011) PMID 21526458

    We found a postcapillary PH (PH group 2 - PH with left heart diseases/diastolic dysfunction). Case 2 also showed a postcapillary PH and a high cardiac output of 9.7 l/min. In case 3, unmasked after dialysis, a precapillary, pulmonary arterial hypertension (PAH - group 1) was detected. TREATMENT AND...
  2. HIV infection and pulmonary arterial hypertension.
    Stefania Cicalini, Pierangelo Chinello, ... Nicola Petrosillo

    Expert Rev Respir Med 5(2):257-66 (2011) PMID 21510735

    Pulmonary arterial hypertension (PAH) is a rare but severe disease that results from chronic obstruction of small pulmonary arteries, leading to right ventricular failure and, ultimately, death. One established risk factor for the development of PAH is HIV infection. In comparison with the incidence...
  3. HIV infection and pulmonary arterial hypertension.
    Cicalini S, Chinello P, ... Petrosillo N

    Expert Rev Respir Med 5(2):257-66 (2011) PMID 21510735

    Pulmonary arterial hypertension (PAH) is a rare but severe disease that results from chronic obstruction of small pulmonary arteries, leading to right ventricular failure and, ultimately, death. One established risk factor for the development of PAH is HIV infection. In comparison with the incidence...