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Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome.

Alexia M AM Thomas, Nghiem N Bui, Jennifer R JR Perkins, Lisa A LA Yuva-Paylor, and Richard R Paylor

Psychopharmacology (Berl) 219(1):47-58 (2012) PMID 21656124

Studies in the Fmr1 knockout (KO) mouse, a model of fragile X syndrome (FXS), suggest that excessive signaling through group I metabotropic glutamate receptors (mGluRs), comprised of subtypes mGluR1 and mGluR5, may play a role in the pathogenesis of FXS. Currently, no studies have assessed the effect of mGluR1 modulation on Fmr1 KO behavior, and there has not been an extensive behavioral analysis of mGluR5 manipulation in Fmr1 KO mice.

DOI: 10.1007/s00213-011-2375-4
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