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99mTc-HYNIC-spermine for imaging polyamine transport system-positive tumours: preclinical evaluation.

Sabrina S Pesnel, Yves Y Guminski, Arnaud A Pillon, Stéphanie S Lerondel, Thierry T Imbert, Nicolas N Guilbaud, Anna A Kruczynski, Christian C Bailly, and Alain A Le Pape

Eur J Nucl Med Mol Imaging 38(10):1832-41 (2011) PMID 21660624

F14512 exploiting the polyamine transport system (PTS) for tumour cell delivery has been described as a potent antitumour agent. The optimal use of this compound will require a probe to identify tumour cells expressing a highly active PTS that might be more sensitive to the treatment. The aim of this study was to design and characterize a scintigraphic probe to evaluate its uptake in cancer cells expressing the PTS.

DOI: 10.1007/s00259-011-1857-2
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