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Apoptosis resistance of mucosal lymphocytes and IL-10 deficiency in patients with steroid-refractory Crohn's disease.

Rebeca Santaolalla, Josep Mañé, Elisabet Pedrosa, Violeta Lorén, Fernando Fernández-Bañares, Josefa Mallolas, Anna Carrasco, Antonio Salas, Mercè Rosinach, Montserrat Forné, Jorge C Espinós, Carme Loras, Michael Donovan, Pere Puig, Miriam Mañosa, Miquel A Gassull, Josep M Viver, and Maria Esteve

Inflamm Bowel Dis 17(7):1490-500 (2011) PMID 21674705

Apoptosis resistance of T-cells is considered an abnormality of immune pathways in Crohn's disease (CD). It has been previously shown that corticosteroids induce apoptosis of cells involved in inflammation. Thus, our aim was to assess the apoptosis of mononuclear cells and pro/antiinflammatory cytokines in the intestinal mucosa of patients with active CD, related to steroid response, and identify cellular and molecular factors that may predict this response to therapy.

DOI: 10.1002/ibd.21507
Version: za2963e q8zab q8zb0 q8zc9 q8zd7 q8ze5 q8zf8 q8zg8

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