Drug-drug interactions with statins: will pitavastatin overcome the statins' Achilles' heel?

Curr Med Res Opin 27(8):1551-62 (2011) PMID 21682551

As the clinical complexity of patients at high cardiovascular risk and with multiple comorbid conditions increases, so does the potential for drug-drug interactions (DDIs). Large retrospective studies in various clinical settings have shown that an unacceptably large proportion of patients are coprescribed a statin with potentially interacting therapies, suggesting that the impact of polypharmacy on the safety profile of statins may be underappreciated.