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Successful treatment with adalimumab in a familial case of gastrointestinal Behcet's disease.

Chiara De Cassan, Bénédicte De Vroey, Catherine Dussault, Eric Hachulla, Sebastien Buche, and Jean-Frédéric Colombel

J Crohns Colitis 5(4):364-8 (2011) PMID 21683309

We present here two siblings with a history of recurrent oral and genital ulcers, neurological and gastrointestinal manifestations. The diagnosis of Behçet's disease in a context of familial aggregation was assumed. Facing repeated steroid-dependent flares and failure of maintenance therapies with colchicine and intolerance to pentoxifilline and disulone, adalimumab was started. Rapid response was observed in both patients, with clinical remission after induction therapy, which currently sustains under maintenance schedule. This case report suggests the effectiveness of adalimumab as first anti-TNFα in case of steroid-dependent/resistant gastrointestinal BD. Copyright © 2011 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

Copyright © 2011 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.crohns.2011.03.006
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