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Glia instruct developmental neuronal remodeling through TGF-β signaling.

Takeshi Awasaki, Yaling Huang, Michael B O'Connor, and Tzumin Lee

Nat Neurosci 14(7):821-3 (2011) PMID 21685919 PMCID PMC3337551

We found that glia secrete myoglianin, a TGF-β ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.

DOI: 10.1038/nn.2833
Version: za2963e q8za2 q8zb2 q8zc5 q8zd1 q8ze5 q8zf3 q8zg4
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