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Biomarkers of kidney injury

Anja Urbschat, Nicholas Obermüller, and Axel Haferkamp

Biomarkers 16(S1):S22-S30 (2011) PMID 21707441

Acute kidney injury (AKI) represents a common serious clinical problem. Up to date mortality due to AKI, especially in intensive care units, has not been changed significantly over the past 50 years. This is partly due to a delay in initiating renal protective and appropriate therapeutic measures since until now there are no reliable early-detecting biomarkers. The gold standard, serum creatinine, displays poor specificity and sensitivity with regard to recognition of the early period of AKI. Objective: Our objective was to review established markers versus novel urine and serum biomarkers of AKI in humans, which have progressed to clinical phase with regard to their diagnostic and prognostic value.

DOI: 10.3109/1354750X.2011.587129
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