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Effects of delayed and extended antioxidant treatment on acute acoustic trauma.

Chul-Hee CH Choi, Kejian K Chen, Xiaoping X Du, Robert A RA Floyd, and Richard D RD Kopke

Free Radic Res 45(10):1162-72 (2011) PMID 21756051

Hair cell death caused by acute acoustic trauma (AAT) reaches a secondary maximum at 7-10 days after noise exposure due to a second oxidative stress. Therefore, this study tested the effects of a combination of hydroxylated alpha-phenyl-tert-butylnitrone (4-OHPBN), N-acetyl-L-cysteine (NAC) and acetyl-L-carnitine (ALCAR) on AAT when the duration of treatment was extended over the period of 7-10 days after noise exposure as well as when the initial treatment was delayed 24 to 48 h after noise exposure.

DOI: 10.3109/10715762.2011.605360
Version: za2963e q8za9 q8zb6 q8zc1 q8zdc q8zee q8zfb q8zg7
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