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Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer.

Lecia V LV Sequist, Joachim J von Pawel, Edward G EG Garmey, Wallace L WL Akerley, Wolfram W Brugger, Dora D Ferrari, Yinpu Y Chen, Daniel B DB Costa, David E DE Gerber, Sergey S Orlov, Rodryg R Ramlau, Susan S Arthur, Igor I Gorbachevsky, Brian B Schwartz, and Joan H JH Schiller

J Clin Oncol 29(24):3307-15 (2011) PMID 21768463

c-MET (MET) receptor activation is associated with poor prognosis and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance in non-small-cell lung cancer (NSCLC). This global, randomized phase II trial examined erlotinib plus tivantinib (ARQ 197; ArQule, Woburn, MA), a novel MET inhibitor.

DOI: 10.1200/JCO.2010.34.0570
Version: za2963e q8zad q8zbc q8zc0 q8zd9 q8ze6 q8zf4 q8zg0
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