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Genome-wide association study of the child behavior checklist dysregulation profile.

Eric E Mick, James J McGough, Sandra S Loo, Alysa E AE Doyle, Janet J Wozniak, Timothy E TE Wilens, Susan S Smalley, James J McCracken, Joseph J Biederman, and Stephen V SV Faraone

J Am Acad Child Adolesc Psychiatry 50(8):807-17.e8 (2011) PMID 21784300 PMCID PMC3143361

A potentially useful tool for understanding the distribution and determinants of emotional dysregulation in children is a Child Behavior Checklist profile, comprising the Attention Problems, Anxious/Depressed, and Aggressive Behavior clinical subscales (CBCL-DP). The CBCL-DP indexes a heritable trait that increases susceptibility for later psychopathology, including severe mood problems and aggressive behavior. We have conducted a genome-wide association study of the CBCL-DP in children with attention-deficit/hyperactivity disorder (ADHD).

DOI: 10.1016/j.jaac.2011.05.001
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