Radiochemotherapy is leading the universal research effort in fighting lethality: it is improving relapse-free survival of patients with inoperable glioblastoma, the most pernicious brain tumor in adults. Its effectiveness was found to depend on expression of Mgmt gene of tumor DNA reparation following radiochemotherapy and adequate medication based on the molecular phenotype of tumor. Our study involved a 40-year old male with a low level of Mgmt gene expression as established by stereotactic biopsy. The patient received hypofractionated three-dimensional conformational proton therapy with the benefit of temozolomide (140 mg/24 hr). Subsequently, the dose was raised to 360 mg/24 hr, on days 1-5 of the cycle. Contrast-enhanced MRI examination established significant diminishing of the size of tumors on completion of cycles 7 and 8; patients felt better, memory and blood indices improved. As of the time this paper was written, relapse-free survival was 17.5 months, as compared with the literature data on inoperable glioblastoma--5.5 months.
We present an analysis of the publicly available HARPS radial velocity (RV)
Measurements for Alpha Cen B, a star hosting an Earth-mass planet candidate in
A 3.24 day orbit. The goal is to devise robust ways of extracting low-amplitude
RV signals of low mass planets in the presence of activity noise....
We study the influence of outer Solar System architecture on the structural
Evolution of the Oort Cloud (OC) and the flux of Earth-crossing comets. In
Particular, we seek to quantify the role of the giant planets as "planetary
Protectors". To do so, we have run simulations in each of four different...
We presented a long slit coronagraph (LSC), for
Which the presence of a slit in the coronagraphic focal plane induces a complex
Distribution of energy in the Lyot pupil-plane that cannot be easily masked
With a binary Lyot stop. To alleviate this concern, we propose to use a pupil
Apodization to sup...
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