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Isolation and characterization of aphidicolin and chlamydosporol derivatives from Tolypocladium inflatum.

Jie J Lin, Xiaoyan X Chen, Xiaoyue X Cai, Xinfang X Yu, Xingzhong X Liu, Ya Y Cao, and Yongsheng Y Che

J Nat Prod 74(8):1798-804 (2011) PMID 21812410

Six new secondary metabolites including two aphidicolin analogues, inflatins A (1) and B (2), and four chlamydosporol derivatives, inflatins C-F (3-6), have been isolated from the crude extract of Tolypocladium inflatum. The structures of 1-6 were determined mainly by NMR experiments, and 4 and 5 were further confirmed by X-ray crystallography. The absolute configurations of C-16 in 1 and C-5 in 3 were deduced via the circular dichroism data of the in situ formed [Rh₂(OCOCF₃)₄] complexes, whereas that of 4 was assigned by X-ray crystallography using Cu Kα radiation. Compounds 1 and 2 showed modest cytotoxicity against a panel of eight human tumor cell lines.

DOI: 10.1021/np200431k
Version: za2963e q8za6 q8zb4 q8zcb q8zdf q8ze0 q8zfe q8zg7

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