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Rivaroxaban versus warfarin in nonvalvular atrial fibrillation.

Manesh R MR Patel, Kenneth W KW Mahaffey, Jyotsna J Garg, Guohua G Pan, Daniel E DE Singer, Werner W Hacke, Günter G Breithardt, Jonathan L JL Halperin, Graeme J GJ Hankey, Jonathan P JP Piccini, Richard C RC Becker, Christopher C CC Nessel, John F JF Paolini, Scott D SD Berkowitz, Keith A A KA Fox, Robert M RM Califf, and

N Engl J Med 365(10):883-91 (2011) PMID 21830957

The use of warfarin reduces the rate of ischemic stroke in patients with atrial fibrillation but requires frequent monitoring and dose adjustment. Rivaroxaban, an oral factor Xa inhibitor, may provide more consistent and predictable anticoagulation than warfarin.

DOI: 10.1056/NEJMoa1009638
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