Prenatal stress (PS) increases the risk of depressive disorders in adult offspring. The pathophysiology of depressive disorders has been linked to hippocampal dysfunction; however, whether and how PS attenuates the development and function of hippocampal networks remains unknown. Using a rat model of PS, in which pregnant mothers receive daily restraint stress during late gestation and their offspring exhibit depressive-like behavior later in life, we show that PS impairs the morphological and functional maturation of hippocampal granule cells in adult offspring via the downregulated expression of mineralocorticoid receptors. PS reduced the dendritic complexity and spine density of neonatal-generated granule cells, which persists into adulthood. These granule cells exhibited depressed synaptic responses to stimulation of the medial perforant path. We further revealed that the expression of mineralocorticoid receptors, which we found is necessary for proper dendritic maturation in this study, was significantly downregulated in granule cells after PS. These results suggest that PS-induced downregulation of mineralocorticoid receptors attenuates neuronal maturation, which results in dysfunction of neuronal network in adulthood.
We report a universal
Phenomenon of synchronization in networks of randomly connected neurons. We
Show that the dynamics of such systems is governed by an interplay between the
Mean and the variance of neuronal activity. We construct a low-dimensional
Representation of the system, explaining the eme...
We show that protons
Accelerated in the forward shock powered by a magnetar wind pushing the ejecta
Launched during the merger process would interact with photons generated in the
Dissipating magnetar wind and emit high energy neutrinos and photons. We
Estimate the typical energy and fluence of the...
We present experimental and theoretical
Results on axonal growth and interconnectivity in order to elucidate some of
The basic rules that neuronal cells use for functional connections with one
Another. We demonstrate that a unidirectional nanotextured surface can bias
Axonal growth. We perform a sys...
Pubget Updates sends you emails when Pubget finds new papers that match your search. Use Pubget Updates to get the latest articles for your specialty, written by a colleague, or published by your favorite journals.