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Targeted regional injection of biocomposite microspheres alters post-myocardial infarction remodeling and matrix proteolytic pathways.

Jennifer A JA Dixon, Robert C RC Gorman, Robert E RE Stroud, Rupak R Mukherjee, Evan C EC Meyer, Nathaniel L NL Baker, Masato M Morita, Hirotsugu H Hamamoto, Liam P LP Ryan, Joseph H JH Gorman, and Francis G FG Spinale

Circulation 124(11 Suppl):S35-45 (2011) PMID 21911817 PMCID PMC3218562

Although localized delivery of biocomposite materials, such as calcium hydroxyapatite (CHAM), have been demonstrated to potentially attenuate adverse left ventricular (LV) remodeling after myocardial infarction (MI), the underlying biological mechanisms for this effect remain unclear. This study tested the hypothesis that targeted CHAM injections would alter proteolytic pathways (matrix metalloproteinases [MMPs] and tissue inhibitors of MMPs [TIMPs]) and would be associated with parameters of post-MI LV remodeling.

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