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Characterization and tissue-specific expression patterns of the Plasmodium chabaudi cir multigene family.

Petra P Ebbinghaus and Jürgen J Krücken

Malar J (2011) PMID 21929749

Variant antigens expressed on the surface of parasitized red blood cells (pRBCs) are important virulence factors of malaria parasites. Whereas Plasmodium falciparum erythrocyte membrane proteins 1 (PfEMP1) are responsible for sequestration of mature parasites, little is known about putative ligands mediating cytoadherence to host receptors in other Plasmodium species. Candidates include members of the pir superfamily found in the human parasite Plasmodium vivax (vir), in the simian pathogen Plasmodium knowlesi (kir) and in the rodent malarias Plasmodium yoelii (yir), Plasmodium berghei (bir) and Plasmodium chabaudi (cir). The aim of this study was to reveal a potential involvement of cir genes in P. chabaudi sequestration.

DOI: 10.1186/1475-2875-10-272
Version: za2963e q8zad q8zbe q8zc3 q8zdd q8zed q8zfb q8zga
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