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[Role of polymorphous genes of xenobiotic biotransformation system in pathogenesis of occupational allergic dermatoses].

L P LP Kuz'mina, N I NI Izmerova, and M M MM Koliaskina

Med Tr Prom Ekol (2011) PMID 21938920

Studying genetic polymorphism of xenogiotics biotransformation system genes in patients with occupational allergic dermatoses, the authors revealed reliably higher percentage of polymorphous variants of CYP 1A1 *2C and EPHX1 A-415G genes, if compared with reference population. Combination of 3 polymorphous variants of xenobiotics biotransformation system genes (CYP 1A1, CYP3A4, EPHX1, GSTM1 and GSTT1) is characterized by earlier development, severe course and unfavorable prognosis of occupational skin condition.

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