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Diseases in a dish: modeling human genetic disorders using induced pluripotent cells.

Gustavo G Tiscornia, Erica Lorenzo EL Vivas, and Juan Carlos JC Izpisúa Belmonte

Nat Med 17(12):1570-6 (2011) PMID 22146428

The derivation of induced pluripotent cells (iPSCs) from individuals suffering from genetic syndromes offers new opportunities for basic research into these diseases and the development of therapeutic compounds. iPSCs can self renew and can be differentiated to many cell types, offering a potentially unlimited source of material for study. In this review we discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs.

DOI: 10.1038/nm.2504
Version: za2963e q8za5 q8zb3 q8zc3 q8zd7 q8zeb q8zf1 q8zg3
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