Purpose: Little information exists about the long-term outcome of amyoplasia. In this article, a case report of a 93-year old woman is presented including both the development of the physical limitations and coping strategies. Method: The medical records, physical examinations and personal interviews during the last 10 years, autobiographical essays and personal photographs were included. Results: Eleven surgical procedures were performed during childhood and ten during adulthood. Ambulation without aids was possible up to the age of 37 years. Thereafter, the muscular force declined gradually, first in the legs and later in the arms. Musculoskeletal pain decreased during ageing. There was an increasing demand to use technical aids. Seniority brought about several diseases, which complicated the quality of life. The woman stayed 32 years of her life in work. Conclusions: A high age can be achieved with amyoplasia although the disability increases due to a gradual deterioration of muscular force. The personal experiences of the woman suggest that her active and creative attitude towards her disability may have contributed to the quality of her life. This may encourage people with amyoplasia and their care givers. [Box: see text].