The synthesis of five amino phosphorus derivatives, 1a-e, is described. The derivatives were incorporated into a series (18) of analogues of the 5-14 portion of angiotensinogen, in most cases at the scissile Leu-Val bond. The resultant compounds were tested in vitro for their ability to inhibit human plasma renin. Replacement of the scissile bond with the phosphinic analogue of Leu10-Val11 (1b) gave the most potent inhibitors, having IC50 = 7.5 x 10(-8) M for H-Pro-His-Pro-Phe-His-(1b)-Ile-His-Lys-OH and IC50 = 1.0 x 10(-7) M for Z-Arg-Arg-Pro-Phe-His-(1b)-Ile-His-NH2. The shorter phosphonic acid sequence Z-Pro-Phe-His-(1d) retained biological activity with an IC50 = 6.4 x 10(-6) M.
Demonstrate magnetoelectric coupling in a metal-organic framework
[(CH3)2NH2]Mn(HCOO)3 which exhibits an order-disorder type of ferroelectricity
Below 185 K. The magnetic susceptibility starts to deviate from the Curie-Weiss
Law at the paraelectric-ferroelectric transition temperature, suggesting...
We investigate the amplitude and phase effects of qubit dynamics and
Excited-state population under the influence of a biharmonic control field. It
Is demonstrated that the biharmonic driving field can have a significant effect
On the behavior of quasi-energy level crossing as well as on multiphoton...
The quantum measurement problem is revisited and discussed in terms of a new
solvable measurement model which basic ingredient is the quantum model of a
controlled single-bit memory. The structure of this model involving strongly
coupled spin and quantum harmonic oscillator allows to define stable...
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