The effects of thyroxine and its related derivatives on gamma-aminobutyric acid (GABA) receptors in the rat brain were examined. D-Thyroxine strongly inhibited [3H]flunitrazepam binding to benzodiazepine receptor in crude synaptic membrane from the rat brain. The Scatchard analysis of the [3H]flunitrazepam binding in the presence of D-thyroxine indicated the decreases in the affinity and maximum number of binding site. Furthermore, D-thyroxine inhibited the enhancing effect of flunitrazepam on GABA-stimulated 36Cl- influx into membrane vesicles, although GABA-stimulated 36Cl- influx alone was not affected by D-thyroxine. On the other hand, the effects of thyroxine and its related derivatives on cerebral GABAB receptor binding were not noted. These results suggest that D-thyroxine may be a drug which is able to modulate the function of GABAA receptor complex via the inhibitory action on benzodiazepine recognition site.
Analyze defect stability and pattern selection in a generalized Swift-Hohenberg
Model of visual cortical development symmetric under the Euclidean group E(2).
Euclidean symmetry strongly influences the geometry and multistability of model
Solutions but does not directly impact on defect stability...
Analytically calculate the density of pinwheels predicted by a pattern
Formation model of visual cortical development. An important factor controlling
The density of pinwheels in this model appears to be the presence of non-local
Long-range interactions, a property which distinguishes cortical ci...
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