Absence of a newly described cytochrome b from neutrophils of patients with chronic granulomatous disease.

doi:10.1016/S0140-6736(78)91445-9

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Absence of a newly described cytochrome b from neutrophils of patients with chronic granulomatous disease.

A W Segal, O T Jones, D Webster and A C Allison Lancet 2(8087):446-9 (1978) PMID 79807

A unique cytochrome b which becomes incorporated into phagocytic vacuoles has been described in human neutrophils. This cytochrome b appears to be situated in the plasma membrane of these cells, and acts as a component of the microbicidal oxidase system. Absence or gross abnormality of this cytochrome b was demonstrated in all four patients with chronic granulomatous disease who were investigated, and reduced concentrations in two mothers known to be carriers of the disease.

DOI: 10.1016/S0140-6736(78)91445-9
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