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The gene responsible for LEC hepatitis, located on rat chromosome 16, is the homolog to the human Wilson disease gene.
N N Sasaki, Y Y Hayashizaki, M M Muramatsu, Y Y Matsuda, Y Y Ando, T T Kuramoto, T T Serikawa, T T Azuma, A A Naito and T T Agui
Biochem Biophys Res Commun 202(1):512-8 (1994)
PMID 8037756
We identified the rat homolog to the human Wilson disease (WD) gene as the gene responsible for hepatitis (hts) in the Long Evans Cinnamon (LEC) rat. A genetic study using fifty-three backcross progenies showed that the rat WD gene detected by Southern blotting using the human WD gene as a probe was tightly linked to the hts phenotype of the LEC rat with no recombination. LEC is a transcriptionally deficient mutant because no transcript of the rat WD gene could be found in the LEC rat by Northern blotting. This rat WD gene was mapped to 16q12.23-12.3 by fluorescence in situ hybridization and mouse x rat somatic cell hybrid analysis.
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DOI:
Version: za2963e q8zae q8zb0 q8zc7 q8zd8 q8ze5 q8zf1 q8zg5