Fetal damage despite low-phenylalanine diet after conception in a phenylketonuric woman.

doi:10.1016/S0140-6736(79)90456-2

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Fetal damage despite low-phenylalanine diet after conception in a phenylketonuric woman.

I I Smith, M M Erdohazi, F J FJ Macartney, J R JR Pincott, O H OH Wolff, D P DP Brenton, S A SA Biddle, D V DV Fairweather and J J Dobbing Lancet 1(8106):17-9 (1979) PMID 83464

A woman with phenylketonuria gave birth to an infant with a cardiac defect and microcephaly despite introduction of a low-phenylalanine diet 5 weeks after conception (3 weeks after the first missed period). In maternal phenylketonuria fetal damage leading to reduced brain growth and cardiac malformations probably occurs within a few weeks of conception.

DOI: 10.1016/S0140-6736(79)90456-2
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Fetal damage despite low-phenylalanine diet after conception in a phenylketonuric woman.

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