Evidence that Alzheimer neurofibrillary tangles originate from neurotubules.

doi:10.1016/S0140-6736(79)91006-7

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Evidence that Alzheimer neurofibrillary tangles originate from neurotubules.

I I Grundke-Iqbal, A B AB Johnson, H M HM Wisniewski, R D RD Terry and K K Iqbal Lancet 1(8116):578-80 (1979) PMID 85165

Antiserum against normal human neurotubules purified by in-vitro assembly precipitated both neurotubules and a polypeptide isolated from Alzheimer neurofibrillary tangles in Ouchterlony double-diffusion tests. The antiserum specifically labelled neurofibrillary tangles, in isolated neurons by immunofluorescence and in tissue sections by the peroxidase-antiperoxidase technique. These results indicate that neurofibrillary tangles in Alzheimer's disease probably originate from neurotubules.

DOI: 10.1016/S0140-6736(79)91006-7
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Evidence that Alzheimer neurofibrillary tangles originate from neurotubules.

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