Advanced search×

A new drug delivery system using plasma-irradiated pharmaceutical aids. V. Controlled release of theophylline from plasma-irradiated double-compressed tablet composed of a wall material containing polybenzylmethacrylate.

M M Ishikawa, T T Noguchi, J J Niwa, and M M Kuzuya

Chem Pharm Bull (Tokyo) 43(12):2215-20 (1995) PMID 8582024

A controlled-release tablet was obtained by oxygen plasma irradiation on the outer layer of double-compressed tablets prepared from theophylline as a core material and a copolymer of methylmethacrylate (MMA) and benzylmethacrylate (BzMA) as a single wall material, making this possible that polybenzylmethacrylate (PBzMA) has dual intramolecular functions, a plasma degradable main chain and a plasma-cross-linkable benzyl group in the side chain as an effect of plasma irradiation. It was shown that the dissolution profiles can be varied so as to cause release of theophylline at different rates, depending on the set of conditions chosen for tablet manufacture and for plasma operation.

Version: za2963e q8za8 q8zbc q8zc6 q8zdc q8ze4 q8zff q8zg8

Similar articles you may find interesting…

  1. Tigloylshikonin, a new minor Shikonin derivative, from the roots and the commercial root extract of lithospermum erythrorhizon.
    Yusai Ito, Kenichi Onobori, ... Yoko Kawamura

    Chem Pharm Bull (Tokyo) 59(1):117-9 (2011) PMID 21212559

    Tigloylshikonin, a new shikonin derivative esterified with tiglic acid ((E)-2-methylbut-2-enoic acid), was isolated as a minor pigment from a food colorant "Shikon color," a commercial root extract from Lithospermum erythrorhizon SIEBOLD et ZUCCARINI. The structure of tigloylshikonin was elucidated...
  2. Synthesis of possible metabolites of 1-cyclopropyl-1,4-dihydro-6-fluoro-5-methyl-7-(3-methyl-1-piperazinyl)- 4-oxo-3-quinolinecarboxylic aci...
    S S Morita, K K Otsubo, ... M M Uchida

    Chem Pharm Bull (Tokyo) 43(12):2246-52 (1995) PMID 8582026

    Grepafloxacin (1-cyclopropyl-1,4-dihydro-6-fluoro-5-methyl-7-(3-methyl-1-piperazinyl )-4-oxo-3-quinoline-carboxylic acid, OPC-17116) (1) exhibits potent and broad-spectrum in vitro and in vivo antibacterial activity. In order to identify the structures of the metabolites of grepafloxacin, 17 possibl...
  3. New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress
    Michael B Sporn, Karen T Liby, ... Gordon W Gribble

    J Nat Prod 74(3):537-545 (2011) PMID 21309592

    We review the original rationale for the development and the chemistry of a series of new synthetic oleanane triterpenoids (SO), based on oleanolic acid (1) as a starting material. Many of the new compounds that have been made, such as 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ("CDDO", 8), a...