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Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7. I. Taxonomy of producing organism, fermentation and biological activity.

K S KS Lam, G A GA Hesler, D R DR Gustavson, R L RL Berry, K K Tomita, J L JL MacBeth, J J Ross, D D Miller, and S S Forenza

J Antibiot (Tokyo) 49(9):860-4 (1996) PMID 8931718

Strain C39217-R109-7 (ATCC 53791) is an actinomycete strain isolated from a soil sample collected at Puerto Viejo, Peru. It produces a new antitumor antibiotic, designated pyrrolosporin A. Taxonomic studies on its morphological, cultural and physiological characteristics identified this producing strain as Micromonospora sp. C39217-R109-7. Pyrrolosporin A shows antimicrobial activity against Gram-positive bacteria and it is weakly active against Gram-negative bacteria. Pyrrolosporin A prolongs the life span of mice inoculated with P388 leukemia cells.

DOI: 10.7164/antibiotics.49.860
Version: za2963e q8zac q8zbe q8zc7 q8zd3 q8ze7 q8zf0 q8zg5

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