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Giant cell granulamatous hypophysitis with remarkable uptake on Gallium-67 scintigraphy.

C C Shimizu, M M Kubo, H H Kijima, A A Ishizu, T T Katoh, and T T Koike

Clin Endocrinol (Oxf) 49(1):131-4 (1998) PMID 9797857

We treated a man with giant cell granulomatous hypophysitis with pituitary enlargement, as seen on magnetic resonance imaging. Endocrinological examination revealed panhypopituitarism and diabetes insipidus. Microscopic examination of the specimen obtained by transsphenoidal pituitary biopsy revealed a granulomatous lesion, composed of epitheliod cells, Langhans' multinucleated giant cells, lymphocytes and other chronic inflammatory cells. On whole body gallium-67 scintigraphy, there was extensive uptake in the pituitary gland. Gallium-67 scintigraphy may greatly aid in the diagnosis of granulomatous hypophysitis.

DOI: 10.1046/j.1365-2265.1998.00417.x
Version: za2963e q8za1 q8zb5 q8zc5 q8zdb q8zed q8zfe q8zg4

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