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  1. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.

    Nature 462(7274):739-44 (2009) PMID 19935646

    We show that cancer-associated IDH1 mutations result in a new ability of the enzyme to catalyse the NADPH-dependent reduction of α-ketoglutarate to R(-)-2-hydroxyglutarate (2HG). Structural studies demonstrate that when arginine 132 is mutated to histidine, residues in the active site are shifted t...
  2. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.

    Nature 452(7184):230-3 (2008) PMID 18337823

    We show that a single switch in a splice isoform of the glycolytic enzyme pyruvate kinase is necessary for the shift in cellular metabolism to aerobic glycolysis and that this promotes tumorigenesis. Tumour cells have been shown to express exclusively the embryonic M2 isoform of pyruvate kinase. Her...