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A Molecular Rheostat at the Interface of Cancer and Diabetes.
ACTA-BIOENERG (2013) PMID 23639840
We discuss how IQGAP1-Exocyst, through differential interactions with Rho-type of small guanosine triphosphatases (GTPases), acts as a rheostat that modulates the mTORC1-Akt and MAPK signals, and integrates β-cell function and mass with insulin signaling, thus providing a molecular mechanism for ca... -
CXCR2 macromolecular complex in pancreatic cancer: a potential therapeutic target in tumor growth.
Transl Oncol 6(2):216-25 (2013) PMID 23544174
We have previously reported that CXCR2 PDZ motif-mediated protein interaction is an important regulator for neutrophil functions. Here, using a series of biochemical assays, we demonstrate that CXCR2 is physically coupled to its downstream effector phospholipase C-β3 (PLC-β3) that is mediated by P... -
Down-regulation of miR-21 Induces Differentiation of Chemoresistant Colon Cancer Cells and Enhances Susceptibility to Therapeutic Regimens.
Transl Oncol 6(2):180-6 (2013) PMID 23544170
We hypothesize that miR-21 plays a critical role in regulating differentiation of CR colon cancer cells. Indeed, we observed that downregulation of miR-21 in CR colon cancer cells (HCT-116 or HT-29) by antisense miR-21 induced differentiation, as evidenced by marked increases in cytokeratin-20 (CK-2... -
Unraveling the mystery of cancer metabolism in the genesis of tumor-initiating cells and development of cancer.
ACTA-BIOENERG (2013) PMID 23523716
We discussed multiple cancer metabolism-related genes (MRGs) that are overexpressed in TICs and are responsible for inducing pluripotent stem cells. Moreover, we summarized that oncogenic metabolic genes and onco-metabolites induce metabolic reprogramming, which switches normal mitochondrial oxidati... -
Synthesis, characterization and anti-tumor activity of novel thymoquinone analogs against pancreatic cancer.
Bioorg Med Chem Lett (2013) PMID 23562242
We report synthesis and characterization of novel TQ analogs appended with gallate and fluorogallate pharmacophores and evaluation of their effects against pancreatic cancer cell lines for cell viability and induction of apoptosis. The efficacy of the analogs alone or in combination with Gemcitabine... -
Tumor Initiating Cells and FZD8 play a major role in drug resistance in Triple- Negative Breast Cancer.
Mol Cancer Ther (2013) PMID 23445611
We initially performed gene expression profiling using the CRL2335 TNBC cell line derived from a squamous breast carcinoma before and after treatment with cisplatin plus TRAIL. We found a significant increase in the expression of FZD8, one of Wnt receptors, and its downstream targets LEF1 and TCF in... -
Tumor Initiating Cells and FZD8 play a major role in drug resistance in Triple- Negative Breast Cancer.
Mol Cancer Ther (2013) PMID 23445611
We initially performed gene expression profiling using the CRL2335 TNBC cell line derived from a squamous breast carcinoma before and after treatment with cisplatin plus TRAIL. We found a significant increase in the expression of FZD8, one of Wnt receptors, and its downstream targets LEF1 and TCF in... -
Antioxidant function of isoflavone and 3,3'-diindolylmethane: Are they important for cancer prevention and therapy?
Antioxid Redox Signal (2013) PMID 23391445
Significance: Oxidative stress has been mechanistically linked with aging and chronic diseases including cancer. In fact, oxidative stress status, chronic disease related inflammation and cancer occurred in aging population are tightly correlated. It is well known that the activation... -
Microenvironment generated during EGFR targeted killing of pancreatic tumor cells by ATC inhibits myeloid-derived suppressor cells through C...
J Transl Med 11(1):35 (2013) PMID 23394575
These data suggest aATC can suppress MDSC differentiation and attenuation of their suppressive activity through down regulation of COX2, PGE2 and ARG1 pathway that is potentiated in presence of Th1 cytokines, suggesting that Th1 enriching immunotherapy may be beneficial in pancreatic cancer treatmen... -
Garcinol sensitizes human pancreatic adenocarcinoma cells to gemcitabine in association with microRNA signatures.
Mol Nutr Food Res 57(2):235-48 (2013) PMID 23293055
Garcinol synergizes with gemcitabine to inhibit cell proliferation and induce apoptosis in PaCa cells with significant modulation of key cancer regulators including PARP, VEGF, MMPs, ILs, caspases, and NF-κB. In addition, biostatistical analyses, quantitative reverse transcription PCR data, and in...
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