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Low-intermediate dose testosterone replacement therapy by different pharmaceutical preparations improves frailty score in elderly hypogonada...
Aging Male (2013) PMID 23517433
Abstract An open-label follow-up study of low-to-intermediate dose testosterone replacement therapy (TRT) was conducted in 64 overweight patients (aged 65-75 years) with late onset hypogonadism (LOH) and increased fasting plasma glucose (FPG). Patients were subdivided into four treat... -
Screening of Cushing's syndrome in outpatients with type 2 diabetes: results of a prospective multicentric study in Italy.
J Clin Endocrinol Metab 97(10):3467-75 (2012) PMID 22767639
The present data do not support widespread screening of patients with type 2 diabetes for Cushing's syndrome; however, the disorder is less rare than previously thought when considering epidemiology of type 2 diabetes. Our results support a case-finding approach in patients with uncontrolled diabetes... -
The impact of long-term exposure to space environment on adult mammalian organisms: a study on mouse thyroid and testis.
PLoS One 7(4):e35418 (2012) PMID 22558148 PMCID PMC3338839
Hormonal changes in humans during spaceflight have been demonstrated but the underlying mechanisms are still unknown. To clarify this point thyroid and testis/epididymis, both regulated by anterior pituitary gland, have been analyzed on long-term space-exposed male C57BL/10 mice, eit... -
Frailty and safety : the example of diabetes.
Drug Saf (2012) PMID 23446787
We will discuss injection treatment with GLP-1 analogues. This review will underline the association between diabetes and some frailty components in old patients and how specific antidiabetic agents may play a specific role in improving outcomes.... -
Metabolic syndrome, adipokines and hormonal factors in pharmacologically untreated adult elderly subjects from the Brisighella Heart Study h...
Obes Facts 5(3):319-26 (2012) PMID 22722758
Men without MS had significantly lower leptin/adiponectin ratio than men with MS. Women without MS had a lower leptin level and leptin/adiponectin ratio than women with MS, but had significantly higher adiponectin, estrone, and deydroepiandrosterone levels. In men, the leptin/adiponectin ratio is th... -
Metabolic consequences of incorrect insulin administration techniques in aging subjects with diabetes.
Acta Diabetol 48(2):121-5 (2011) PMID 20091324
Only few insulin-treated (IT) people with diabetes mellitus (DM) reach the target due to poor compliance and/or to sedentary lifestyle and/or to inadequate treatment regimen. The latter may be also brought about by often overlooked factors including insulin injection into altered ski... -
Adipokines and sexual hormones associated with the components of the metabolic syndrome in pharmacologically untreated subjects: data from t...
Int J Endocrinol (2011) PMID 22114592
We evaluated the association of the sex hormone pattern and the serum level of the main adipokines to metabolic syndrome (MS) and its components in 199 pharmacologically untreated subjects. Men and women included in the age-class subgroups were matched for body mass index, waist circumference, blood... -
Feeding behavior in mammals including humans.
Ann N Y Acad Sci (2009) PMID 19456343
The complex control of food intake and energy metabolism in mammals relies on the ability of the brain to integrate multiple signals indicating the nutritional state and the energy level of the organism and to produce appropriate responses in terms of food intake, energy expenditure, and metabolic a... -
Positive energy balance is associated with accelerated muscle atrophy and increased erythrocyte glutathione turnover during 5 wk of bed rest...
Am J Clin Nutr 88(4):950-8 (2008) PMID 18842781
Positive energy balance during inactivity is associated with greater muscle atrophy and with activation of systemic inflammation and of antioxidant defenses. Optimizing caloric intake may be a useful strategy for mitigating muscle loss during period of chronic inactivity.... -
Effect of conditions of three dimensional clinostating on testicular cell machinery
Acta Astronaut 60(4-7):391-396 (2007)
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