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  • Impairment of cardiovascular autonomic pattern in obese adolescents with Type 2 diabetes mellitus.
    serum lipids were significantly higher in obese and T2DM. Insulin sensitivity was significantly reduced in T2DM and obese vs. contro...
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  • Dissociated effects of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide-1 on beta-cell secretion and insulin clearance in mice.
    We used those GLP-1 results to compare GIP effects with those of GLP-1. C-peptide secretion rate peaked at 1 minute after glucose in...
    Metabolism : (2010)
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  • Alcohol acutely increases vascular reactivity together with insulin sensitivity in type 2 diabetic men.
    We hypothesized that this relates to a direct effect of alcohol and therefore investigated whether acute alcohol intake altered insu...
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  • An empirical index of insulin sensitivity from short IVGTT: validation against the minimal model and glucose clamp indices in patients with different clinical characteristics
    We studied participants with different clinical characteristics who underwent 3 h regular (n = 336) or insulin-modified (n =â€...
    Diabetologia : (2009)
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  • Chronic peripheral hyperinsulinemia in type 1 diabetic patients after successful combined pancreas kidney transplantation does not affect ectopic lipid accumulation in skeletal muscle and liver.
    We investigated the effects of systemic instead of portal insulin release in type-1 diabetic (T1DM) patients after successful pancre...
    Diabetes : (2009)
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  • Beta cell function and insulin sensitivity in women with polycystic ovary syndrome: Influence of the family history of type 2 diabetes mellitus
    Aim. To study the impact of family history (FH) of type 2 diabetes mellitus on β-cell compensatory mechanism in women with po...
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  • Evaluation of different methods for assessment of insulin sensitivity in Gottingen minipigs: introduction of a new, simpler method.
    The use of animal models in diabetes research requires reliable tests for evaluation of insulin sensitivity and beta-cell function....
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  • Effect of iron overload on glucose metabolism in patients with hereditary hemochromatosis.
    We studied both insulin secretion and insulin sensitivity in a cohort of patients with HH. We studied glucose metabolism in 53 newly...
    Metabolism : (2009)
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  • Osteocalcin is related to enhanced insulin secretion in gestational diabetes.
    During pregnancy osteocalcin was significantly higher in GDM compared to NGT (15.6+/-6.4 vs.12.6+/-4.0 ng/ml; p<0.015), while no dif...
    Diabetes Care : (2009)
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  • Adipokines in type-1 diabetes after successful pancreas transplantation: Normal visfatin and retinol-binding-protein-4, but increased total adiponectin fasting concentrations.
    SUMMARY Objective In type-1 diabetes mellitus (T1DM), the release of many hormones, not only from beta-cells, but al...
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  • Beta cell (dys)function in non-diabetic offspring of diabetic patients.
    During the OGTT, the offspring of individuals with type 2 diabetes showed 4-14% higher plasma glucose from 30 to 120 min (p < 0.05)...
    Diabetologia : (2009)
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  • The effect of rosiglitazone on insulin sensitivity, beta cell function, bone mineral density, and body composition in hiv-positive patients on highly-active antiretroviral therapy (HAART).
    Highly active antiretroviral therapy (HAART) leads to lipodystrophy and is associated with detrimental changes in glucose and lipid...
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  • Effects of conjugated linoleic acid plus n-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men.
    The combination was well tolerated. There was no significant difference in fasting levels of glucose, insulin or C-peptide after CLA/...
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  • Short-Term Exercise Training Does Not Stimulate Skeletal Muscle ATP Synthesis in Relatives of Humans With Type 2 Diabetes
    We tested the hypothesis that short-term exercise training improves hereditary insulin resistance by stimulating ATP synthesis and in...
    Diabetes 58:1333 (2009)
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  • Reappraisal of the intravenous glucose tolerance index for a simple assessment of insulin sensitivity in mice.
    Mice are increasingly used in studies where measuring insulin sensitivity (IS) is a common procedure. The glucose clamp is labor int...
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  • Early cardiovascular autonomic dysfunction, beta cell function and insulin resistance in obese adolescents.
    Obese adolescents had higher serum lipids, reduced insulin sensitivity and higher insulin resistance. Obese individuals showed indee...
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  • Free fatty acid kinetics during long-term treatment with pioglitazone added to sulfonylurea or metformin in Type 2 diabetes.
    At Week 104, pioglitazone treatment decreased fasting FFAs by 0.08 mmol L(-1) when added to sulfonylurea and by 0.11 mmol L(-1) when...
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  • Interactions of glucose metabolism and chronic heart failure.
    The study group consisted of 94 CHF patients. Insulin sensitivity (OGIS index) and insulin secretion parameters were investigated by...
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  • Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver.
    Patients with NASH exhibited a prolonged GIP elevation after fat ingestion. GIP response correlated directly with hepatic steatosis,...
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  • Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH.
    We tested if TCF7L2 polymorphism is a risk factor for nonalcoholic fatty liver disease (NAFLD) and if it modulates liver injury, glu...
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