We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose...

Based on their respective antitumor and thrombolytic activities, the superantigen staphylococcal enterotoxin C2 (SEC2) and staphylokinase (Sak) were chosen for the construction of the novel chimeric proteins Sak-linker- SEC2 and SEC2-linker-Sak using a linker composed of nine Ala res...

The largest genome-wide association study of severe asthma to date was carried out and strong evidence found for the association of two previously identified asthma susceptibility loci in patients with severe disease. A number of novel regions with suggestive evidence were also identified warranting...

A 3D macro-assembly with α-MnO(2) nanowires as flexible building blocks was obtained by a simple hydrothermal method. The sample with an interconnected open porous structure shows excellent mechanical strength, selective adsorption of cationic dyes and some certain types of toxic he...

In shallow water, the peak and energy of through signature change because of the stack of reflected sound from the sea bottom and sea surface, it will cause much error in signal process. In this paper, the focused beaming-forming method is introduced in through signature processing....

We describe the discovery and isolation of a paramyxovirus, feline morbillivirus (FmoPV), from domestic cat (Felis catus). FmoPV RNA was detected in 56 (12.3%) of 457 stray cats (53 urine, four rectal swabs, and one blood sample) by RT-PCR. Complete genome sequencing of three FmoPV strains showed ge...

We have previously described mouse monoclonal antibodies (MAbs) to non-overlapping terminal and internal epitopes of the Ft LPS O-polysaccharide (OAg). In the current study, we used Ft LPS oligosaccharides of defined OAg repeat length as molecular rulers in competition ELISA to demonstrate that the...

Mean IKDC score, Tegner-Lysholm outcomes, and Lysholm-Gillquist scale improved from 45, 2.5, and 50, respectively, at surgery to 75, 4, and 70, respectively, at 24-month followup. Complications include periosteal hypertrophy observed in two patients. CONCLUSION: Cell-based therapy was associated wit...

OBJECTIVE. To evaluate the efficacy and safety of a new generation of 2.45-GHz microwave to ablate hepatocellular carcinoma by surgical approach. DESIGN. Case series with prospective follow-up. SETTING. A university teaching hospital in Hong Kong. PATIENTS. From March 2009 to January...

The treatment of articular cartilage lesions is complicated, but novel tissue engineering approaches seem to improve the outcome. A tissue engineering approach is less invasive and reduces surgical time, periosteal hypertrophy, and morbidity. Cell-based therapies using scaffolds have...

A total of eight patients were recruited for this study, but two of them did not receive sclerotherapy. One patient refused treatment after obtaining initial consent, and another patient was not treated due to a technical issue. The median follow-up duration was 21 months. The median cyst volume was...

Pt-Pd bimetallic alloy nanostructures with highly selective morphologies such as cube, bar, flower, concave cube, and dendrite have been achieved through a facile one-pot solvothermal synthesis. The effects of shape-controllers (sodium dodecyl sulfate (SDS), ethylenediamine-tetraacet...

We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10(-8)-1.2×10(-43)). U...

We show that Mediator regulates alternative mRNA processing via its MED23 subunit. Combining tandem affinity purification and mass spectrometry, we identified a number of mRNA processing factors that bind to a soluble recombinant Mediator subunit, MED23, but not to several other Mediator components...

I metabolites was successfully identified with deviations of mass accuracy less than 2 ppm. The biotransformations observed included hydroxylation, dihydroxylation, oxidation of a quaternary methyl group to hydroxymethyl or carboxylic acid groups, dehydrogenation and hydroxylation, as well as demeth...

This study constructs a rat brain T(2) -weighted magnetic resonance imaging template including olfactory bulb and a compatible digital atlas. The atlas contains 624 carefully delineated brain structures based on the newest (2005) edition of rat brain atlas by Paxinos and Watson. An a...