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  • A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients.
    We hypothesized that the extent of vascular normalization will be predictive of outcome of anti-VEGF therapy in glioblastoma. We use...
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  • Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study.
    Thirty-four patients were enrolled. The objective response rate was 2.9%, and 50% of patients had stable disease. Median PFS was 3.9...
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  • Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study.
    Tumors regressed from a mass with mean size of 5 cm (range, 3 to 12 cm) to an ulcer/scar with mean size of 2.4 cm (range, 0.7 to 6.0...
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  • Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice.
    We treated mice bearing three different orthotopic models of glioblastoma with a VEGF-targeted kinase inhibitor, cediranib. Using in...
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  • Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis.
    We first show that both VEGF receptor-2 and VEGF receptor-3 stimulation activate eNOS in lymphatic endothelial cells and that NO don...
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  • Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse.
    We show that targeted ablation of lung capillary endothelial cells recapitulates the cellular events involved in cigarette smoke-ind...
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  • Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model.
    PLoS Med 5:e24 (2008)
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  • A ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11.
    We isolated an IL-11-like peptide mapping to domain I of the IL-11 (sequence CGRRAGGSC). Although this motif has ligand attributes,...
    PLoS ONE 3:e3452 (2008)
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  • The original Pathologische Anatomie Leiden-Endothelium monoclonal antibody recognizes a vascular endothelial growth factor binding site within neuropilin-1.
    We used a combinatorial phage display-based approach ("epitope mapping") to select peptides binding to the original PAL-E antibody....
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  • Treatment of hypoxia-induced retinopathy with targeted proapoptotic peptidomimetic in a mouse model of disease.
    We have previously identified ligands from combinatorial peptide libraries that target tumor vasculature after in vivo selection. Th...
    FASEB J 21:3272 (2007)
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  • Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries.
    We profiled the cell surface of the NCI-60 by high-throughput screening of a phage-displayed random peptide library and classified t...
    Cancer Res 66:34 (2006)
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  • Development of a ligand-directed approach to study the pathogenesis of invasive aspergillosis.
    We adapted a phage display library-based selection to screen and identify binding peptides to the surface of Aspergillus fumigatus c...
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  • Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands.
    We have recently identified glucose-regulated protein-78 (GRP78) as a relevant molecular target expressed in metastatic tumors by fi...
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  • Aminopeptidase A is a functional target in angiogenic blood vessels.
    We show that a membrane-associated protease, aminopeptidase A (APA), is upregulated and enzymatically active in blood vessels of hum...
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  • Model of unidirectional transluminal gene transfer.
    We designed and optimized an intermediate model for assessing and quantifying unidirectional transduction ex vivo. The model enables...
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  • Steps toward mapping the human vasculature by phage display.
    We developed a selection method in which peptides that home to specific vascular beds are identified after administration of a pepti...
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  • An Anti-Angiogenic State in Mice and Humans with Retinal Photoreceptor Cell Degeneration
    We show that neonatal mice with classic inherited retinal degeneration (Pdeb<sup>rd1</sup>/Pdeb<sup>rd1</sup>...
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