Over 9 years of follow-up, 106 women developed gout. The cumulative incidence of gout, by age 70 years, according to BMI category at baseline of <25, 25-29.9, 30-34.9, and ≥35 kg/m(2), was 1.9, 3.6, 7.9, and 11.8%, respectively (P <.001). Obese women (BMI ≥30) at baseline had an adjusted 2.4-fol...

Higher NGAL, but not KIM-1, levels were associated with incident CKD stage 3. Adjustment for urinary creatinine and albumin concentration attenuated this association. Additional studies are needed to confirm these findings and assess the utility of urinary NGAL as a marker of CKD risk....

Chronic kidney disease (CKD) is increasingly recognized as a global health problem. The conditions leading to CKD, the health impact of CKD and the prognosis differ markedly between affected individuals. In particular, renal failure and cardiovascular mortality are competing risks for CKD patients. O...

We hypothesized that SNPs identified in association with estimated GFR (eGFR) would also be associated with albuminuria.MethodsWithin the CKDGen consortium cohort (n=31,580, European ancestry), we tested 16 eGFR-associated SNPs for association with urinary albumin-to-creatinine ratio (UACR) and albu...

Distinct metabolic phenotypes were reproducibly associated with eGFR in 2 separate population studies. They may provide novel insights into renal metabolite handling, improve understanding of pathophysiology, or aid in the diagnosis of kidney disease. Longitudinal studies are needed to clarify wheth...

We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A...

Higher serum apolipoprotein A1 was associated with lower prevalence of CKD and higher eGFR estimated by the CKD-EPI equation in two large multiethnic population-based samples. While apolipoprotein B showed no consistent associations, a higher apolipoprotein B/A1 ratio was significantly associated wi...

We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention....

We report a comprehensive analysis of genotype-dependent metabolic phenotypes using a GWAS with non-targeted metabolomics. We identified 37 genetic loci associated with blood metabolite concentrations, of which 25 show effect sizes that are unusually high for GWAS and account for 10-60% differences...

We identified 16 loci for eGFR in genome-wide association studies, but the associations of these single nucleotide polymorphisms (SNPs) for incident CKD or ESRD are unknown. We thus investigated the association of these loci with incident CKD in 26,308 individuals of European ancestry free of CKD at...

We performed an interrogation of known renal loci, genome-wide association (GWA), and IBC candidate-gene SNP association analyses in African Americans from the CARe Renal Consortium. In up to 8,110 participants, we performed meta-analyses of GWA and IBC array data for estimated glomerular filtration...

We conducted a meta-analysis of GWAS of serum urate levels and gout among 5,820 AA and a large candidate gene study among 6,890 AA and 21,708 European Americans (EA) within the Candidate Gene Association Resource (CARe) Consortium. Findings were tested for replication among 1,996 independent AA indi...

We performed a genome-wide association meta-analysis in 1,283 SCD cases and >20,000 control individuals of European ancestry from 5 studies, with follow-up genotyping in up to 3,119 SCD cases and 11,146 controls from 11 European ancestry studies, and identify the BAZ2B locus as associated with SCD (...

Lower urinary CTGF concentrations precede the onset of CKD stage 3 in the general population. Further work is required to fully characterize how CTGF level influences risk of CKD. Published by Elsevier Inc....

We examined rs4821480, an MYH9 single nucleotide polymorphism (SNP) recently identified as associated with kidney disease in African-Americans, in 13,133 participants from the Framingham Heart and ARIC studies. In addition, we further interrogated the MYH9/APOL1 gene region using 282 SNPs for associ...

We examined genome-wide and candidate gene associations with systolic and diastolic blood pressure (SBP, DBP) using the CARe Consortium consisting of 8,591 AAs. Genotypes included genome-wide SNP data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SN...

Compared with Whites, Blacks had poorer access to health care (3 vs 0.3% with no usual source of health care or health insurance, P < 0.001) and experienced greater CKD incidence (14.7 vs 12.0 cases per 1000 person-years, P < 0.001). Blacks' excess risk of CKD persisted after adjusting for demograph...

Membranous nephropathy has an incidence of approximately 1 case per 100,000 persons per year,1 and its phenotype has been clearly defined on the basis of histologic features, making it a good subject for genomewide association studies. Recognized as a clinicopathological entity in the 1950s,2 membran...