We aimed to compare cytokine and chemokine profiles in different types of cutaneous LE. We investigated lesional mRNA and protein expression of various cytokines and chemokines in patients with chronic discoid LE (CDLE, n=15), subacute cutaneous LE (SCLE, n=11), and lupus erythematosus tumidus (LET,...

This large retrospective analysis confirms recent reports of a high prevalence of LiS in patients with LoS. Based on these findings, patients with LoS, especially those with morphea, should be carefully screened for concomitant LiS, including inspection of the anogenital region. Copy...

269 swabs had valid results in both test formats (111 normal, 10 ASCUS, 105 LSIL, 42 HSIL, 1 AC). For the detection of LSIL+(LSIL+HSIL+cancer) sensitivity, specificity, negative predictive value (NPV) and PPV were 80.4%, 26.4%, 52.5%, and 57.2% for HR-HPV-DNA testing, respectively, compared to 75.7%...

We performed the first successful GWAS of SSc. Here, we perform a large replication study to better dissect the genetic component of SSc.MethodsWe selected 768 polymorphisms from the previous GWAS and genotyped them in seven replication cohorts from Europe. Overall significance was calculated for re...

The histopathology of lichen sclerosus (LS) suggests abnormalities in extracellular matrix (ECM) composition.

We describe an 88-year-old patient with a perianal tumor that was detected during skin cancer screening. Histopathology showed the tumor to be a basal cell carcinoma. Immunohistochemical staining for Ber-EP4 was highly positive, clearly distinguishing the tumor from basaloid anal carcinoma, which is...

Objectives. To assess the prevalence and risk factors of ulnar artery occlusion (UAO) in an unselected SSc patient cohort and to determine whether UAO is associated with digital ulcers (DUs).Methods. A total of 79 SSc patients and 40 'healthy' controls underwent colour duplex sonogra...

We conducted a follow-up study of this locus in different Caucasian cohorts.Patients and Methods We analyzed ten GWAS genotyped single nucleotide polymorphisms (SNPs) in the IL12RB2 region (2,309 SSc patients and 5,161 controls). We then selected three SNPs (rs3790567, rs3790566 and rs924080), based...

A 45-year-old man presented with a 1-year history of discomfort when sitting. Clinical examination of the gluteal cleft revealed a locally destructive, cauliflower-like, verrucous mass measuring 15 cm in diameter. There was no associated regional lymphadenopathy.

We aimed to investigate the expression profiles of different cytokines and chemokines in patients with LS and healthy controls. Twenty patients with plaque-type morphea and 18 healthy controls were investigated. Skin biopsies were performed for real-time RT-PCR studies. Median mRNA of interleukin (I...

Our findings argue against a pathogenic role of MCPyV in KA and SCC. Copyright © 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved....

MCPyV is found - mostly integrated into the host genome - in approximately 80% of MCC. The causal role of MCPyV in MCC development has been corroborated by several recent studies. Cutaneous MCPyV infection is acquired early in life and is widespread in the general population. In HIV-positive patient...