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  • Interaction trap/two-hybrid system to identify interacting proteins.
    The yeast two-hybrid method (or interaction trap) is a powerful technique for detecting protein interactions. The procedure is perfo...
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  • White adipose tissue cells are recruited by experimental tumors and promote cancer progression in mouse models.
    We have shown that stromal cells from white adipose tissue (WAT) cooperate with the endothelium to promote blood vessel formation th...
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  • Combinatorial stem cell mobilization
    Different subsets of bone marrow stem cells can be mobilized by varying drug treatments.
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  • Combinatorial stem cell mobilization.
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  • Tissue-specific targeting based on markers expressed outside endothelial cells.
    Effective management of various diseases could greatly benefit from improved approaches to selective delivery of ima...
    Adv Genet 67:61 (2009)
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  • IFATS Collection: Combinatorial Peptides Identify {alpha}5{beta}1 Integrin as a Receptor for the Matricellular Protein SPARC on Adipose Stromal Cells.
    We screened a combinatorial library for peptide ligands binding to patient-derived ASC. We demonstrate that both primary and culture...
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  • Interaction trap/two-hybrid system to identify interacting proteins.
    The yeast two-hybrid method (or interaction trap) is a powerful technique for detecting protein interactions. The procedure is perfo...
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  • A ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11.
    We isolated an IL-11-like peptide mapping to domain I of the IL-11 (sequence CGRRAGGSC). Although this motif has ligand attributes,...
    PLoS ONE 3:e3452 (2008)
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  • Display technologies: application for the discovery of drug and gene delivery agents.
    Recognition of molecular diversity of cell surface proteomes in disease is essential for the development of targeted therapies. Prog...
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  • Synchronous selection of homing peptides for multiple tissues by in vivo phage display.
    We devised an efficient approach to simultaneously screen phage display libraries for peptides homing to any number of tissues witho...
    FASEB J 20:979 (2006)
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  • Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries.
    We profiled the cell surface of the NCI-60 by high-throughput screening of a phage-displayed random peptide library and classified t...
    Cancer Res 66:34 (2006)
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  • Reversal of obesity by targeted ablation of adipose tissue.
    We report an antiobesity therapy based on targeted induction of apoptosis in the vasculature of adipose tissue. We used in vivo phag...
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  • Teratogenicity Induced by Targeting a Placental Immunoglobulin Transporter
    We investigated mechanisms of teratogen-mediated blockade of maternofetal transport by screening a combinatorial library for peptide...
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  • Teratogenicity induced by targeting a placental immunoglobulin transporter.
    We investigated mechanisms of teratogen-mediated blockade of maternofetal transport by screening a combinatorial library for peptide...
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  • Steps toward mapping the human vasculature by phage display.
    We developed a selection method in which peptides that home to specific vascular beds are identified after administration of a pepti...
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  • Targeting Cyclin-Dependent Kinases in Drosophila with Peptide Aptamers
    We explore the ability to use peptide aptamers as in vivo inhibitors by expressing aptamers directed against cell cycle regulators i...
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