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  • From combinatorial peptide selection to drug prototype (I): Targeting the vascular endothelial growth factor receptor pathway.
    We previously used a combinatorial screening on vascular endothelial growth factor (VEGF)-activated endothelial cells to select the...
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  • From combinatorial peptide selection to drug prototype (II): Targeting the epidermal growth factor receptor pathway.
    We identify small molecules mimicking EGFR and that functionally behave as soluble decoys for EGF and TGFalpha, ligands that would o...
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  • Combinatorial Ligand-directed Lung Targeting.
    We have also designed and developed targeted nanoparticles with imaging capabilities and/or drug delivery functions by combining pha...
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  • An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment
    We uncovered a direct, specific, and functional interaction between CRKL, an adapter protein [with Src homology 2 (SH2)- and SH3-con...
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  • Next-generation phage display: integrating and comparing available molecular tools to enable cost-effective high-throughput analysis.
    We gained efficiency by applying in tandem real-time PCR for rapid quantification to enable bacteria-free phage display library scre...
    PLoS ONE 4:e8338 (2009)
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  • Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse.
    We show that targeted ablation of lung capillary endothelial cells recapitulates the cellular events involved in cigarette smoke-ind...
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  • A ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11.
    We isolated an IL-11-like peptide mapping to domain I of the IL-11 (sequence CGRRAGGSC). Although this motif has ligand attributes,...
    PLoS ONE 3:e3452 (2008)
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  • Impaired angiogenesis in aminopeptidase N-null mice.
    We evaluated, by targeted disruption of the APN gene, whether APN participates in blood vessel formation and function under normal c...
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  • Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries.
    We profiled the cell surface of the NCI-60 by high-throughput screening of a phage-displayed random peptide library and classified t...
    Cancer Res 66:34 (2006)
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  • Structural basis for the interaction of a vascular endothelial growth factor mimic peptide motif and its corresponding receptors.
    We screened phage display libraries and built a peptide-based ligand-receptor map of binding sites within the VEGF family. We then v...
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  • Design and validation of a bifunctional ligand display system for receptor targeting.
    We developed a bacteriophage display particle designed to serve as a bifunctional entity that can target tumors while delivering an...
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  • Aminopeptidase A is a functional target in angiogenic blood vessels.
    We show that a membrane-associated protease, aminopeptidase A (APA), is upregulated and enzymatically active in blood vessels of hum...
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  • Steps toward mapping the human vasculature by phage display.
    We developed a selection method in which peptides that home to specific vascular beds are identified after administration of a pepti...
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  • Heparanase-2 and syndecan-1 in colon cancer: the ugly ducklings or the beautiful swans?
    These results confirm earlier observations that Syn-1 is downregulated by colorectal carcinoma cells but raise questions about its p...
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