We aimed to compare the current incidence and other demographic attributes of PIBD in the Scottish population to previous data....

Natalizumab is a humanised monoclonal antibody targeting the lymphocyte adhesion molecule a4 integrin, with proven efficacy in multiple sclerosis (MS) and Crohn's disease (CD). The development of sarcoidosis with extrapulmonary involvement is reported in two patients with refractory...

Background  Although population-based studies of patients with Crohn's disease (CD) suggest only a modestly increased mortality, recent data have raised concerns regarding the outcome of CD patients requiring hospitalisation. Aim  To determine the mortality and contributory facto...

We will detail the presently available data on the genetic overlap between IBD and other diseases. The discussion will be informed by the epidemiological data in the published literature and the implications for pathogenesis and therapy will be outlined. This arena will move forwards very quickly in...

These data provide an important insight into the impact of epigenetic mechanisms in the pathogenesis of CD. (Inflamm Bowel Dis 2011;). Copyright © 2011 Crohn's & Colitis Foundation of America, Inc....

ObjectiveThe NOX2 NADPH oxidase complex produces reactive oxygen species and plays a critical role in the killing of microbes by phagocytes. Genetic mutations in genes encoding components of the complex result in both X-linked and autosomal recessive forms of chronic granulomatous di...

Studies of human tissue samples and knockout mice demonstrated a role for the guanosine triphosphatase RAC1 in the development of ulcerative colitis; increased expression of RAC1 was associated with susceptibility to colitis. Copyright © 2011 AGA Institute. Published by Elsevier Inc...

We identified 6 NOD2-interacting proteins (TLE1, GALNT2, HTATIP, Vimentin, FIS1, and PPP2R5E). Of these, expression of GALNT2 (CD, P =.004) and vimentin (CD, P =.006; UC, P =.0025) was altered in patients with IBD, compared with controls. SNPs within TLE1were associated with susceptibility to CD, sp...

: COX-2 A-1195G polymorphism was associated with the risk of UC, especially among never-smokers, suggesting that low activity of COX-2 may predispose to UC. Our results suggest that inclusion of smoking status may be essential for the evaluation of the role of genetic predisposition to IBD. (Inflamm...