The Shh pathway plays a role in the proliferation of NPCs induced by ischemia/hypoxia and might participate in injury remodeling....

We show that ischemia induces sustained contraction of pericytes on microvessels in the intact mouse brain. Pericytes remain contracted despite successful reopening of the middle cerebral artery after 2 h of ischemia. Pericyte contraction causes capillary constriction and obstructs erythrocyte flow....

We have previously demonstrated that the cyclin-dependent kinase inhibitor (CKI) p21(cip1/waf1) (p21) maintains the quiescence of neural stem-like cells under cerebral ischemia, as similarly shown for the hematopoietic stem cells. Here, we report the distinct role of another CKI member, p27(kip1) (p...

The basal bleeding time was prolonged by 24 +/- 3% (mean +/- SE) when the samples were incubated with 500 microM of L-arginine. The NOS inhibitor L-N(5)-(I-iminoethyl)ornithine reversed this effect, suggesting that it was mediated by NO. After statin treatment, the NO-mediated prolongation of the bl...

We have therefore analyzed the brain distribution of the enzymatic activity of the S1P synthesizing enzyme, sphingosine kinase (SPHK) [EC:2.7.1.91], as well as mRNA distribution for one of the two isoforms of this enzyme, sphingosine kinase 2. SPHK activity, measured by the conversion of [(3)H]sphin...

We use functional magnetic resonance imaging (fMRI) to evaluate the therapeutic efficacy of albumin and its effects on the recovery of stimuli-induced cerebral hemodynamics. For this purpose, fMRI activity in the ipsilesional somatosensory (SS) cortex was assessed using a well established rat model...

We present a patient with relapsing polychondritis who presented with findings of lateral medullary syndrome, known as the syndrome of Wallenberg, produced by infarction of a wedge of lateral medulla lying posterior to the inferior olivary nucleus. Angiographic examination showed complete occlusion...

The present study was designed to determine bone density modifications at the forearm and metacarpal bones in patients with carpal tunnel syndrome (CTS). Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry at the one-third distal end and for the total of the radius-ulna, toge...

The mean SSR amplitude values in patients compared with controls were 337 +/- 244 versus 1897 +/- 848 (P < 0.0001) for right hemispheric lesions and 466 +/- 398 versus 1873 +/- 843 (P < 0.0001) for left hemispheric lesions. The mean SSR latencies in patients compared with controls were 1526 +/- 163...

We investigated the effects of aspirin (300 mg/d), ticlopidine (500 mg/d) and their low-dose combination (aspirin 100 mg/d plus ticlopidine 250 mg/d) on the platelet aggregability using the Wu and Hoak method. Each treatment group consisted of 25 patients with acute ischemic stroke. Platelet aggrega...

I (starting at 18 Hz and then testing at 2, 6, 8, 10, 15, 20, 30, 40, 50, 60 Hz) and protocol II (stimulating at 2, 6, 8, 10, 15, 18, 20, 30, 40, 50, 60 Hz). Protocol I was used for patients not known to be photosensitive whereas protocol II was used for patients known to be photosensitive before re...