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  • From combinatorial peptide selection to drug prototype (II): Targeting the epidermal growth factor receptor pathway.
    We identify small molecules mimicking EGFR and that functionally behave as soluble decoys for EGF and TGFalpha, ligands that would o...
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  • From combinatorial peptide selection to drug prototype (I): Targeting the vascular endothelial growth factor receptor pathway.
    We previously used a combinatorial screening on vascular endothelial growth factor (VEGF)-activated endothelial cells to select the...
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  • Processing of the Matricellular Protein Hevin in Mouse Brain Is Dependent on ADAMTS4.
    We now report proteolysis of hevin in many tissues, with the most extensive processing in the brain. We demonstrate a cleavage site...
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  • RETRACTED BY PUBLISHER: Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1.
    This paper is retracted by publisher as it was posted in error prior to review.
    J Biol Chem : (2010)
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  • Cracking the code for compartment-specific dual functionality proteins in cancer: The case for CRKL.
    Cell Cycle 9: (2010)
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  • Reactive antibodies against bacillus Calmette-Guerin heat-shock protein-65 potentially predict the outcome of immunotherapy for high-grade transitional cell carcinoma of the bladder
    An immunogenic peptide motif was selected, isolated, and validated from M. bovis BCG heat-shock protein 65 (HSP-65) as a dominant ep...
    Cancer 116:600 (2009)
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  • Combinatorial Ligand-directed Lung Targeting.
    We have also designed and developed targeted nanoparticles with imaging capabilities and/or drug delivery functions by combining pha...
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  • Phase II Presurgical Feasibility Study of Bevacizumab in Untreated Patients With Metastatic Renal Cell Carcinoma
    PurposeTo assess safety and efficacy of presurgical bevacizumab in patients with metastatic renal cell carcinoma (mRCC), and to explo...
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  • Role of leukemia cell invadosome in extramedullary infiltration
    We hypothesized that a supramolecular complex, the leukemia-cell invadosome, which contains certain integrins, matrix metalloprotein...
    Blood 114:3008 (2009)
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  • A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phage-mediated, vascular-targeted suicide gene transfer.
    We recently reported that selective systemic delivery of suicide genes such as herpes simplex virus thymidine kinase (HSVtk) to tumo...
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  • White adipose tissue cells are recruited by experimental tumors and promote cancer progression in mouse models.
    We have shown that stromal cells from white adipose tissue (WAT) cooperate with the endothelium to promote blood vessel formation th...
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  • Targeting cancer-specific synthetic lethality in double-strand DNA break repair.
    We review here the rationale for this strategy, describe examples of its application, and outline potential strengths and weaknesses...
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  • Extracellular and intracellular mechanisms that mediate the metastatic activity of exogenous osteopontin.
    : In the extracellular environment, the results confirmed that soluble osteopontin is required for its prometastatic effects; this ph...
    Cancer 115:1753 (2009)
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  • An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment
    We uncovered a direct, specific, and functional interaction between CRKL, an adapter protein [with Src homology 2 (SH2)- and SH3-con...
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  • Discovery of a functional protein complex of netrin-4, laminin γ1 chain, and integrin α6β1 in mouse neural stem cells
    We present a protein complex that controls proliferation and migration of adult NSCs destined for the mouse olfactory bulb (OB). Com...
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  • The Interleukin-11 Receptor {alpha} as a Candidate Ligand-Directed Target in Osteosarcoma: Consistent Data from Cell Lines, Orthotopic Models, and Human Tumor Samples.
    We evaluated IL-11Ralpha as a candidate target in primary and metastatic human osteosarcoma. First, in an orthotopic mouse model, we...
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  • Ligand-directed cancer gene therapy to angiogenic vasculature.
    Gene therapy strategies in cancer have remained an active area of preclinical and clinical research. One of the curr...
    Adv Genet 67:103 (2009)
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  • Intravascular delivery of particulate systems: does geometry really matter?
    In cancer therapy and imaging, the systemic passive delivery of particulate systems has relied on the enhanced permeability and rete...
    Pharm Res 26:235 (2009)
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  • Tumor vasculature-targeted delivery of tumor necrosis factor-alpha*.
    In vitro, AAVP-TNF-alpha infection of human melanoma cells resulted in high levels of TNF-alpha expression. Systemic administration...
    Cancer 115:128 (2009)
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  • Peptidase substrates via global peptide profiling.
    Peptide metabolism is a complex process that involves many proteins working in concert. Mass spectrometry-based global peptide profi...
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